How did mankind's way of relating to God change in Genesis 4:26?
From Sensus Plenior
Ge 4:26 And to Seth, to him also there was born a son; and he called his name Enos: then began men to call upon the name of the LORD.
Ps 116:13 I will take the cup of salvation, and call upon the name of the LORD.
Ps 116:17 I will offer to thee the sacrifice of thanksgiving, and will call upon the name of the LORD.
Zep 3:9 For then will I turn to the people a pure language, that they may all call upon the name of the LORD, to serve him with one consent.
Ro 10:13 For whosoever shall call upon the name of the Lord shall be saved.
The scriptures indicate that calling on the name of the Lord is a good thing. They became closer to God.